Sasikumar was born to a Malayali family in Thiruvananthapuram, Kerala. He began his education at the local St. Joseph's School and later attended the University of Kerala. Sasikumar's entry into cinema was quite early, as he began working as a child artist in Malayalam films. His debut film was the 1949 Malayalam movie "Kumara Kuyil." He continued to work in Malayalam cinema throughout the 1950s and 1960s, appearing in small roles.

Sasikumar's entry into Tamil cinema was marked by his debut film "Thangathotti" in 1952. However, it was his role in the 1960 film "Kavalai Vendam" that brought him recognition and acclaim. Throughout the 1960s, Sasikumar appeared in a string of successful Tamil films, including "Thenpandi Cheemayile" (1966), "Poova Thalaiya" (1967), and "Uyirippira" (1967).

Sasikumar has also produced several films under his banner, Sasikumar Productions. One of his notable productions was the 2007 film "Pallu Padama Paathuka," which was directed by him as well. The film was a critical and commercial success, and Sasikumar's production house has since produced several other successful films.